Article
Cardiac amyloidosis in African Americans: comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosis.
American heart journal - 1 Oct 2009
Connors Lawreen H, Prokaeva Tatiana, Lim Amareth, Théberge Roger, Falk Rodney H, Doros Gheorghe, Berg Alan, Costello Catherine E, O'Hara Carl, Seldin David C, Skinner Martha
Abstract excerpt
BACKGROUND: Transthyretin (TTR) mutations known to cause cardiac amyloidosis include V122I, found almost exclusively in African Americans at a prevalence of 3-3.9%. This retrospective study describes TTR V122I-associated cardiac amyloid disease (ATTR) in a major amyloid referral clinic population. METHODS: Self-identified African Americans with amyloidosis (n = 156) were screened for TTR V122I by serum...
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