Article
Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing.
Journal of virology - 1 Mar 2011
Salazar-Gonzalez Jesus F, Salazar Maria G, Learn Gerald H, Fouda Genevieve G, Kang Helen H, Mahlokozera Tatenda, Wilks Andrew B, Lovingood Rachel V, Stacey Andrea, Kalilani Linda, Meshnick Steve R, Borrow Persephone, Montefiori David C, Denny Thomas N, Letvin Norman L, Shaw George M, Hahn Beatrice H, Permar Sallie R
Abstract excerpt
HIV transmission via breastfeeding accounts for a considerable proportion of infant HIV acquisition. However, the origin and evolution of the virus population in breast milk, the likely reservoir of transmitted virus variants, are not well characterized. In this study, HIV envelope (env) genes were sequenced from virus variants amplified by single-genome amplification from plasmas and milk of 12 chronically...
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