Article
Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission.
PloS one - 20 Apr 2010
Heath Laura, Conway Susan, Jones Laura, Semrau Katherine, Nakamura Kyle, Walter Jan, Decker W Don, Hong Jason, Chen Thomas, Heil Marintha, Sinkala Moses, Kankasa Chipepo, Thea Donald M, Kuhn Louise, Mullins James I, Aldrovandi Grace M
Abstract excerpt
BACKGROUND: Breast milk transmission of HIV-1 remains a major route of pediatric infection. Defining the characteristics of viral variants to which breastfeeding infants are exposed is important for understanding the genetic bottleneck that occurs in the majority of mother-to-child transmissions. The blood-milk epithelial barrier markedly restricts the quantity of HIV-1 in breast milk, even in the absence of...
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