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Article

A fungal anticodon nuclease ribotoxin exploits a secondary cleavage site to evade tRNA repair.

RNA (New York, N.Y.) - 1 Sept 2012

Meineke Birthe, Kast Alene, Schwer Beate, Meinhardt Friedhelm, Shuman Stewart, Klassen Roland

Abstract excerpt

PaOrf2 and γ-toxin subunits of Pichia acaciae toxin (PaT) and Kluyveromyces lactis zymocin are tRNA anticodon nucleases. These secreted ribotoxins are assimilated by Saccharomyces cerevisiae, wherein they arrest growth by depleting specific tRNAs. Toxicity can be recapitulated by induced intracellular expression of PaOrf2 or γ-toxin in S. cerevisiae. Mutational analysis of γ-toxin has identified amino acids...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22836353
DOI: 10.1261/rna.034132.112
PMCID: PMC3425785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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