Article
Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator.
Molecular microbiology - 1 Nov 2001
Jablonowski D, Frohloff F, Fichtner L, Stark M J, Schaffrath R
Abstract excerpt
The putative Kluyveromyces lactis zymocin target complex, TOT, from Saccharomyces cerevisiae comprises five Tot proteins, four of which are RNA polymerase II (RNAP II) Elongator subunits. Recently, two more Elongator subunit genes, ELP6 (TOT6) and ELP4 (TOT7), have been identified. Deletions of both TOT6 and TOT7 result in the complex tot phenotype, including resistance to zymocin, thermosensitivity, slow growth...
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