Article
Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids.
The Journal of biological chemistry - 18 Mar 2011
Broadhead Geoffrey K, Mun Hee-chang, Avlani Vimesh A, Jourdon Orane, Church W Bret, Christopoulos Arthur, Delbridge Leigh, Conigrave Arthur D
Abstract excerpt
γ-Glutamyl peptides were identified previously as novel positive allosteric modulators of Ca(2+)(o)-dependent intracellular Ca(2+) mobilization in HEK-293 cells that bind in the calcium-sensing receptor VFT domain. In the current study, we investigated whether γ-glutamyl-tripeptides including γ-G...
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