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Article

Residue 826 in the calcium-sensing receptor is implicated in the response to calcium and to R-568 calcimimetic compound.

Calcified tissue international - 1 Mar 2010

Alvarez-Hernández Daniel, González-Suárez Ignacio, Fernández-Martín José L, Rodríguez Isabel, Santamaría Iñigo, Coto Eliecer, Cannata-Andía Jorge B

Abstract excerpt

Within the extracellular loops of the seven-transmembrane domain of the calcium-sensing receptor (CaR) there is a region (I819-E837) relevant for calcimimetic activity. As the naturally occurring variant Ala826Thr is within this important region, it may be postulated that this change may influence the CaR response to calcium and R-568. Human embryonic kidney (HEK-293) cells transiently transfected with three...

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Identifiers

PMID: 20130845
DOI: 10.1007/s00223-009-9298-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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