Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Residue 826 in the calcium-sensing receptor is implicated in the response to calcium and to R-568 calcimimetic compound.

Calcified tissue international - 1 Mar 2010

Alvarez-Hernández Daniel, González-Suárez Ignacio, Fernández-Martín José L, Rodríguez Isabel, Santamaría Iñigo, Coto Eliecer, Cannata-Andía Jorge B

Abstract excerpt

Within the extracellular loops of the seven-transmembrane domain of the calcium-sensing receptor (CaR) there is a region (I819-E837) relevant for calcimimetic activity. As the naturally occurring variant Ala826Thr is within this important region, it may be postulated that this change may influenc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Aniline Compounds
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Signaling

Share to Flow Cytometry

Share to Mutagenesis, Site-Directed

Share to Protein Structure, Tertiary

Share to Receptors, Calcium-Sensing

Source

Identifiers

PMID: 20130845
DOI: 10.1007/s00223-009-9298-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20130845-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Residue 826 in the calcium-sensing receptor is implicated in the response to calcium and to R-568 calcimimetic compound.PMID 20130845Read ↗

Calcimimetic R-568 effects on activity of R990G polymorphism of calcium-sensing receptor.Semantic proximity Read ↗

Novel inactivating mutations of the calcium-sensing receptor: the calcimimetic NPS R-568 improves signal transduction of mutant receptors.Semantic proximity Read ↗

Novel Activating Mutations of the Calcium-Sensing Receptor: The Calcilytic NPS-2143 Mitigates Excessive Signal Transduction of Mutant ReceptorsSemantic proximity Read ↗

A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+.Semantic proximity Read ↗

Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators.Semantic proximity Read ↗

Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site.Semantic proximity Read ↗

Novel activating mutations of the calcium-sensing receptor: the calcilytic NPS-2143 mitigates excessive signal transduction of mutant receptors.Semantic proximity Read ↗

Loss-of-function and gain-of-function mutations of calcium-sensing receptor: functional analysis and the effect of allosteric modulators NPS R-568 and NPS 2143.Semantic proximity Read ↗

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders.Semantic proximity Read ↗

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.Semantic proximity Read ↗

Modulation and action of the calcium-sensing receptor.Semantic proximity Read ↗

Identification and characterization of D410E, a novel mutation in the loop 3 domain of CASR, in autosomal dominant hypocalcemia and a therapeutic approach using a novel calcilytic, AXT914.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.