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Article

Calcimimetic R-568 effects on activity of R990G polymorphism of calcium-sensing receptor.

Journal of molecular endocrinology - 1 Oct 2010

Terranegra Annalisa, Ferraretto Anita, Dogliotti Elena, Scarpellini Milena, Corbetta Sabrina, Barbieri Anna Maria, Spada Anna, Arcidiacono Teresa, Rainone Francesco, Aloia Andrea, Cusi Daniele, Vezzoli Giuseppe, Soldati Laura

Abstract excerpt

Previous studies have demonstrated a gain-of-function of the calcium-sensing receptor (CASR) gene R990G polymorphism. In this study, activation of the R990G CASR stably transfected in HEK-293 (HEK-990G) cells compared with that of the common variant (HEK-wild-type (WT)) by increasing concentrations of CaCl(2) or calcimimetic R-568 caused significantly higher intracellular free calcium concentration ([Ca(2+)](i))...

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Identifiers

PMID: 20682641
DOI: 10.1677/JME-10-0034

Genes

CASR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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