Article
Inhibition of T-cell proliferation by murine multipotent mesenchymal stromal cells is mediated by CD39 expression and adenosine generation.
Cell transplantation - 1 Jan 2011
Sattler Christine, Steinsdoerfer Manuela, Offers Monika, Fischer Elke, Schierl Rudolf, Heseler Kathrin, Däubener Walter, Seissler Jochen
Abstract excerpt
Multipotent mesenchymal stromal cells (MSCs) are bone marrow-derived cells of nonhematopoietic origin with immunoregulatory properties. Although some functions of MSCs have been identified, there are still features that are not explained thus far. The aim of the present study was to identify novel factors involved in MSC-mediated inhibition of T-cell proliferation. We here demonstrate that the surface molecule...
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