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Article

The importance of glutathione and glutathione transferase for somatic mutations in Drosophila melanogaster induced in vivo by 1,2-dichloroethane.

Carcinogenesis - 1 Aug 1990

Romert L, Magnusson J, Ramel C

Abstract excerpt

Two principal pathways of metabolism of the carcinogenic compound 1,2-dichloroethane (DCE) have been proposed. One is a mixed function oxidase dependent pathway requiring oxygen and NADPH. The other pathway depends on the presence of glutathione (GSH) and glutathione transferase (GST). The aim of this study was to investigate the role of the latter pathway for the in vivo mutagenicity of DCE in the somatic wing...

Topics

Aflatoxins
Animals
Buthionine Sulfoximine
Drosophila melanogaster
Ethylene Dichlorides
Female
Glutathione
Glutathione Transferase
Hydrocarbons, Chlorinated
Male
Methionine Sulfoximine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenobarbital

Source

Identifiers

PMID: 2117503
DOI: 10.1093/carcin/11.8.1399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2117503-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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