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Article

T (brachyury) gene duplication confers major susceptibility to familial chordoma.

Nature genetics - 1 Nov 2009

Yang Xiaohong R, Ng David, Alcorta David A, Liebsch Norbert J, Sheridan Eamonn, Li Sufeng, Goldstein Alisa M, Parry Dilys M, Kelley Michael J

Abstract excerpt

Using high-resolution array-CGH, we identified unique duplications of a region on 6q27 in four multiplex families with at least three cases of chordoma, a cancer of presumed notochordal origin. The duplicated region contains only the T (brachyury) gene, which is important in notochord development and is expressed in most sporadic chordomas. Our findings highlight the value of screening for complex genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19801981
DOI: 10.1038/ng.454
PMCID: PMC2901855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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