Article
Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization.
PloS one - 10 Dec 2010
Baum Patrick, Schmid Ramona, Ittrich Carina, Rust Werner, Fundel-Clemens Katrin, Siewert Susanne, Baur Martin, Mara Lisa, Gruenbaum Lore, Heckel Armin, Eils Roland, Kontermann Roland E, Roth Gerald J, Gantner Florian, Schnapp Andreas, Park John E, Weith Andreas, Quast Karsten, Mennerich Detlev
Abstract excerpt
A phenocopy is defined as an environmentally induced phenotype of one individual which is identical to the genotype-determined phenotype of another individual. The phenocopy phenomenon has been translated to the drug discovery process as phenotypes produced by the treatment of biological systems with new chemical entities (NCE) may resemble environmentally induced phenotypic modifications. Various new chemical...
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