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Article

Unveiling the mysteries of clopidogrel metabolism and efficacy.

Clinical pharmacology and therapeutics - 1 Dec 2011

Bonello L, Bonello N, Grosdidier C, Camoin-Jau L

Abstract excerpt

Clopidogrel is an important antiplatelet agent, but a considerable variability in the biological effect of the drug has been observed. Additionally, patients with insufficient platelet reactivity inhibition following a loading dose (LD) of clopidogrel have a poor outcome. The mechanisms of variability are dependent on genetic polymorphisms of enzymes involved in clopidogrel metabolism. Paraoxonase 1 has been...

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Identifiers

PMID: 22089343
DOI: 10.1038/clpt.2011.222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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