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Article

Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility.

Investigative ophthalmology & visual science - 1 Mar 2011

Spencer Kylee L, Olson Lana M, Schnetz-Boutaud Nathalie, Gallins Paul, Wang Gaofeng, Scott William K, Agarwal Anita, Jakobsdottir Johanna, Conley Yvette, Weeks Daniel E, Gorin Michael B, Pericak-Vance Margaret A, Haines Jonathan L

Abstract excerpt

PURPOSE: Age-related macular degeneration (AMD) is a complex disorder of the retina, characterized by drusen, geographic atrophy, and choroidal neovascularization. Cigarette smoking and the genetic variants CFH Y402H, ARMS2 A69S, CFB R32Q, and C3 R102G have been strongly and consistently associated with AMD. Multiple linkage studies have found evidence suggestive of another AMD locus on chromosome 16p12 but the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21169531
DOI: 10.1167/iovs.09-5112
PMCID: PMC3101690

Genes

CACNG3
ARMS2
CFB
CFH
ITGAM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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