Article
Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions.
American journal of human genetics - 1 Aug 2004
Weeks Daniel E, Conley Yvette P, Tsai Hui-Ju, Mah Tammy S, Schmidt Silke, Postel Eric A, Agarwal Anita, Haines Jonathan L, Pericak-Vance Margaret A, Rosenfeld Philip J, Paul T Otis, Eller Andrew W, Morse Lawrence S, Dailey J P, Ferrell Robert E, Gorin Michael B
Abstract excerpt
Age-related maculopathy (ARM), or age-related macular degeneration, is one of the most common causes of visual impairment in the elderly population of developed nations. In a combined analysis of two previous genomewide scans that included 391 families, containing up to 452 affected sib pairs, we found linkage evidence in four regions: 1q31, 9p13, 10q26, and 17q25. We now have added a third set of families and...
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