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Article

Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope.

Journal of molecular biology - 11 Feb 2011

Lowe David C, Gerhardt Stefan, Ward Alison, Hargreaves David, Anderson Malcolm, Ferraro Franco, Pauptit Richard A, Pattison Debbie V, Buchanan Catriona, Popovic Bojana, Finch Donna K, Wilkinson Trevor, Sleeman Matthew, Vaughan Tristan J, Mallinder Philip R

Abstract excerpt

Interleukin (IL) 15 is an inflammatory cytokine that plays an essential role in the activation, proliferation, and maintenance of specific natural killer cell and T-cell populations, and has been implicated as a mediator of inflammatory diseases. An anti-IL-15 antibody that blocked IL-15-dependent cellular responses was isolated by phage display and optimised via mutagenesis of the third...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21167836
DOI: 10.1016/j.jmb.2010.12.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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