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Article

Evidence for adaptive evolution at the divergence between lymphoid and brain HIV-1 nef genes.

AIDS research and human retroviruses - 1 Apr 2010

Olivieri Kevin C, Agopian Kristin A, Mukerji Joya, Gabuzda Dana

Abstract excerpt

Human immunodeficiency virus type 1 (HIV) infection of the central nervous system frequently causes HIV-associated neurocognitive disorders (HAND). The role of HIV Nef and other accessory proteins in HAND pathogenesis is unclear. To determine whether HIV nef undergoes adaptive selection in brain, we cloned 100 nef sequences (n = 30 brain and n = 70 lymphoid) from four patients with AIDS and HIV-associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20377428
DOI: 10.1089/aid.2009.0257
PMCID: PMC2933169

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PACS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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