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Article

PAX3 knockdown in metastatic melanoma cell lines does not reduce MITF expression.

Melanoma research - 1 Feb 2011

He Shujie, Li Caiyun G, Slobbe Lynn, Glover Amy, Marshall Elaine, Baguley Bruce C, Eccles Michael R

Abstract excerpt

PAX3 and MITF are important transcriptional activators in the melanocyte lineage and PAX3 is thought to control MITF expression during normal melanocyte differentiation. However, it is not clear whether this is still true in melanoma and whether the effects of knockdown of PAX3 on the inhibition of melanoma growth or survival are by its regulation of MITF. By western blot and quantitative real-time reverse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21164369
DOI: 10.1097/CMR.0b013e328341c7e0

Genes

MITF
PAX3
FOXD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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