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Article

Inhibition of early stages of HIV-1 assembly by INI1/hSNF5 transdominant negative mutant S6.

Journal of virology - 1 Mar 2011

Cano Jennifer, Kalpana Ganjam V

Abstract excerpt

INI1/hSNF5 is an HIV-1 integrase (IN) binding protein specifically incorporated into virions. A truncated mutant of INI1 (S6, amino acids 183 to 294) harboring the minimal IN binding Rpt1 domain potently inhibits HIV-1 particle production in a transdominant manner. The inhibition requires interaction of S6 with IN within Gag-Pol. While INI1 is a nuclear protein and harbors a masked nuclear export signal (NES),...

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Share to Amino Acid Motifs
Share to Chromosomal Proteins, Non-Histone
Share to HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nuclear Localization Signals

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Share to SMARCB1 Protein

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Source

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Identifiers

PMID: 21159874
DOI: 10.1128/JVI.00006-10
PMCID: PMC3067803

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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