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Article

HIV-1 replication in cell lines harboring INI1/hSNF5 mutations.

Retrovirology - 31 Aug 2006

Sorin Masha, Yung Eric, Wu Xuhong, Kalpana Ganjam V

Abstract excerpt

BACKGROUND: INI1/hSNF5 is a cellular protein that directly interacts with HIV-1 integrase (IN). It is specifically incorporated into HIV-1 virions. A dominant negative mutant derived from INI1 inhibits HIV-1 replication. Recent studies indicate that INI1 is associated with pre-integration and reverse transcription complexes that are formed upon viral entry into the target cells. INI1 also is a tumor suppressor,...

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Share to Transcription, Genetic
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Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Genes, Tumor Suppressor

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to SMARCB1 Protein

Source

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Identifiers

PMID: 16945155
DOI: 10.1186/1742-4690-3-56
PMCID: PMC1592304

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Source receipt: pubmed, retrieved 7 Sept 2026.

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