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Article

Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1/ mice with collagen-induced chronic arthritis.

BMC musculoskeletal disorders - 16 Dec 2010

Jochems Caroline, Islander Ulrika, Erlandsson Malin, Engdahl Cecilia, Lagerquist Marie, Gjertsson Inger, Ohlsson Claes, Holmdahl Rikard, Carlsten Hans

Abstract excerpt

BACKGROUND: Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-ncf1*/*mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-ncf1*/*mice, CIA develops as a chronic relapsing...

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Identifiers

PMID: 21159208
DOI: 10.1186/1471-2474-11-284
PMCID: PMC3009959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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