Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Screening for common copy-number variants in cancer genes.

Cancer genetics and cytogenetics - 1 Dec 2010

Tyson Jess, Majerus Tamsin M O, Walker Susan, Armour John A L

Abstract excerpt

For most cases of colorectal cancer that arise without a family history of the disease, it is proposed that an appreciable heritable component of predisposition is the result of contributions from many loci. Although progress has been made in identifying single nucleotide variants associated with colorectal cancer risk, the involvement of low-penetrance copy number variants is relatively unexplored. We have used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Deletion
Share to Chromosomes, Human, Pair 3
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Genes, Neoplasm

Share to Introns

Share to Nucleic Acid Hybridization

Source

Identifiers

PMID: 21156252
DOI: 10.1016/j.cancergencyto.2010.08.008

Genes

APC
MLH1
AXIN1
BRCA1
BRCA2
CTNNB1
HRAS
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Screening for common copy-number variants in cancer genes.PMID 21156252Read ↗

Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients.Semantic proximity Read ↗

Chromosome copy number analysis in screening for prognosis-related genomic regions in colorectal carcinoma.Semantic proximity Read ↗

High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization.Semantic proximity Read ↗

Germline copy number polymorphisms involving larger than 100 kb are uncommon in normal subjects.Semantic proximity Read ↗

Genome-wide copy neutral LOH is infrequent in familial and sporadic microsatellite unstable carcinomas.Semantic proximity Read ↗

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas.Semantic proximity Read ↗

Incidental copy-number variants identified by routine genome testing in a clinical population.Semantic proximity Read ↗

Zoom-in array comparative genomic hybridization (aCGH) to detect germline rearrangements in cancer susceptibility genes.Semantic proximity Read ↗

Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomasSemantic proximity Read ↗

Frequent occurrence of uniparental disomy in colorectal cancer.Semantic proximity Read ↗

Dosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification.Semantic proximity Read ↗

Uniparentalism in sporadic colorectal cancer is independent of imprint status, and coordinate for chromosomes 14 and 18.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.