Article
Germline copy number polymorphisms involving larger than 100 kb are uncommon in normal subjects.
The Prostate - 15 Feb 2007
Liu Wennuan, Chang Baoli, Li Tao, Dimitrov Latchezar, Kim Seungchan, Kim Jin Woo, Turner Aubrey R, Meyers Deborah A, Trent Jeffery M, Zheng Siqun Lilly, Isaacs William B, Xu Jianfeng
Abstract excerpt
BACKGROUND: Recent studies using ROMA and Array-CGH suggest that germline copy number polymorphisms (CNPs) involving >100 kb are common in humans. METHODS: In this study, we used the Affymetrix GeneChip 100K single nucleotide polymorphisms (SNP) mapping panel to further examine the type and frequency of germline CNPs in the genome. By utilizing the allele intensity data generated while genotyping approximately...
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