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Article

Dosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification.

British journal of cancer - 13 Sept 2004

Bunyan D J, Eccles D M, Sillibourne J, Wilkins E, Thomas N Simon, Shea-Simonds J, Duncan P J, Curtis C E, Robinson D O, Harvey J F, Cross N C P

Abstract excerpt

Multiplex ligation-dependent probe amplification (MLPA) is a recently described method for detecting gross deletions or duplications of DNA sequences, aberrations which are commonly overlooked by standard diagnostic analysis. To determine the incidence of copy number variants in cancer predisposi...

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Source

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Identifiers

PMID: 15475941
DOI: 10.1038/sj.bjc.6602121
PMCID: PMC2747696

Genes

FAP
BRCA1
BRCA2
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15475941-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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