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[CTLA-4 gene polymorphism regulates CTLA-4 mRNA stability and protein level in patients with ulcerative colitis].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Dec 2010

Chen Zhi-tao, Xia Bing, Jiang Ting, Zhou Feng, Zou Kai-fang, Ge Liu-qing

Abstract excerpt

OBJECTIVE: To investigate the effect of (AT)n repeat polymorphism of the 3'untranslated region in cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) gene on CTLA-4 mRNA stability and full length (flCTLA-4) and soluble CTLA4 (sCTLA-4) expression in ulcerative colitis (UC). METHODS: flCTLA-4 mRNA in colonic biopsies and sCTLA-4 mRNA stability in peripheral blood mononuclear cells of UC patients were measured by...

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Antigens, CD
Case-Control Studies
Colitis, Ulcerative
CTLA-4 Antigen
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21154316
DOI: 10.3760/cma.j.issn.1003-9406.2010.06.001

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CTLA4

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