Article
Molecular genetic analysis of U2AF59 in Schizosaccharomyces pombe: differential sensitivity of introns to mutational inactivation.
RNA (New York, N.Y.) - 1 Jan 1999
Romfo C M, Lakhe-Reddy S, Wise J A
Abstract excerpt
The large subunit of the mammalian U2AF heterodimer (U2AF65) is essential for splicing in vitro. To expand our understanding of how this protein functions in vivo, we have created a null allele of the gene encoding the Schizosaccharomyces pombe ortholog, U2AF59, and employed it in a variety of ge...
Topics
- Amino Acid Sequence
- Cell Cycle Proteins
- Cell Division
- DEAD-box RNA Helicases
- Fungal Proteins
- Gene Expression
- Genetic Complementation Test
- Humans
- Introns
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Phenotype
- RNA Precursors
- RNA Splicing
- RNA, Fungal
- Ribonucleoproteins
- Saccharomyces cerevisiae Proteins