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Article

Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2011

Cai Yujun, Miller Clint L, Nagel David J, Jeon Kye-Im, Lim Soyeon, Gao Pingjin, Knight Peter A, Yan Chen

Abstract excerpt

OBJECTIVE: The phenotypic modulation of vascular smooth muscle cells (VSMCs) to a synthetic phenotype is vital during pathological vascular remodeling and the development of various vascular diseases. An increase in type I collagen (collagen I) has been implicated in synthetic VSMCs, and cyclic n...

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Source

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Identifiers

PMID: 21148428
DOI: 10.1161/ATVBAHA.110.212621
PMCID: PMC4114343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21148428-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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