Article
A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Dec 2010
Chen Bojun, Ge Qian, Xia Xiao-Ming, Liu Ping, Wang Sijie J, Zhan Haiying, Eipper Betty A, Wang Zhao-Wen
Abstract excerpt
The BK channel is a Ca²+- and voltage-gated potassium channel with many important physiological functions. To identify proteins important to its function in vivo, we screened for Caenorhabditis elegans mutants that suppressed a lethargic phenotype caused by expressing a gain-of-function (gf) isoform of the BK channel α-subunit SLO-1. BKIP-1 (for BK channel interacting protein), a small peptide with no significant...
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