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Article

Dystrobrevin controls neurotransmitter release and muscle Ca(2+) transients by localizing BK channels in Caenorhabditis elegans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Nov 2011

Chen Bojun, Liu Ping, Zhan Haiying, Wang Zhao-Wen

Abstract excerpt

Dystrobrevin is a major component of a dystrophin-associated protein complex. It is widely expressed in mammalian tissues, including the nervous system, in which it is localized to the presynaptic nerve terminal with unknown function. In a genetic screen for suppressors of a lethargic phenotype caused by a gain-of-function isoform of SLO-1 in Caenorhabditis elegans, we isolated multiple loss-of-function (lf)...

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Identifiers

PMID: 22131396
DOI: 10.1523/JNEUROSCI.3638-11.2011
PMCID: PMC3233975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dystrobrevin controls neurotransmitter release and muscle Ca(2+) transients by localizing BK channels in Caenorhabditis elegans.PMID 22131396Read ↗

Molecular, genetic and physiological characterisation of dystrobrevin-like (dyb-1) mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels.Semantic proximity Read ↗

The SLO-1 BK channel of Caenorhabditis elegans is critical for muscle function and is involved in dystrophin-dependent muscle dystrophy.Semantic proximity Read ↗

The dystrophin-associated protein complex maintains muscle excitability by regulating Ca(2+)-dependent K(+) (BK) channel localization.Semantic proximity Read ↗

Dystrobrevin- and dystrophin-like mutants display similar phenotypes in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

Overexpression of dystrobrevin delays locomotion defects and muscle degeneration in a dystrophin-deficient Caenorhabditis elegans.Semantic proximity Read ↗

α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells.Semantic proximity Read ↗

SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction.Semantic proximity Read ↗

The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin.Semantic proximity Read ↗

A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans.Semantic proximity Read ↗

Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response.Semantic proximity Read ↗

Dystrophin and functionally related proteins in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

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