Article
Alternatively spliced domains interact to regulate BK potassium channel gating.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011
Johnson Brandon E, Glauser Dominique A, Dan-Glauser Elise S, Halling D Brent, Aldrich Richard W, Goodman Miriam B
Abstract excerpt
Most human genes contain multiple alternative splice sites believed to extend the complexity and diversity of the proteome. However, little is known about how interactions among alternative exons regulate protein function. We used the Caenorhabditis elegans slo-1 large-conductance calcium and voltage-activated potassium (BK) channel gene, which contains three alternative splice sites (A, B, and C) and encodes at...
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