The neurology and natural history of patients with indeterminate CAG repeat length mutations of the Huntington disease gene.

doi:10.1016/j.jns.2010.11.015

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Article

The neurology and natural history of patients with indeterminate CAG repeat length mutations of the Huntington disease gene.

Journal of the neurological sciences - 15 Feb 2011

Panegyres Peter K, Goh Judy G S

Abstract excerpt

OBJECTIVE: This study aims to understand the neurological manifestations of patients with an indeterminate CAG repeat length (36-39) of the Huntingtin gene, HTT. METHODS: A longitudinal evaluation of 10 patients was performed. Duration of follow-up was mean=4.23 years (standard deviation 1.068; 95% CI 3.466-4.994; range 3-6.4 years). Three patients had a CAG repeat length of 37, three 38 and four 39. Mean CAG...

Topics

Adult
Aged
Asymptomatic Diseases
Atrophy
Brain
Cardiovascular Diseases
Cerebral Ventricles
Cognition Disorders
Comorbidity
Cranial Irradiation
Craniotomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Disease Progression

Female

Follow-Up Studies

Humans

Huntingtin Protein

Huntington Disease

Magnetic Resonance Imaging

Source

Open in PubMed

Identifiers

PMID: 21147489
DOI: 10.1016/j.jns.2010.11.015

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