Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Is There Convincing Evidence that Intermediate Repeats in the HTT Gene Cause Huntington's Disease?

Journal of Huntington's disease - 1 Jan 2015

Oosterloo Mayke, Van Belzen Martine J, Bijlsma Emilia K, Roos Raymund A C

Abstract excerpt

BACKGROUND AND OBJECTIVE: Huntington's disease (HD) is a neurodegenerative disease associated with a CAG repeat expansion in the Huntingtin (HTT) gene. A trinucleotide size between 27 and 35 is considered 'intermediate' and not to cause symptoms and signs of HD. There are articles claiming otherwise, however publishing only the cases that have a HD phenotype introduces a significant publication bias. Our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to HTT gene
Share to Huntingtin Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Nerve Tissue Proteins

Share to Phenotype

Share to Trinucleotide Repeat Expansion

Source

Identifiers

PMID: 26397895
DOI: 10.3233/JHD-140120

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is There Convincing Evidence that Intermediate Repeats in the HTT Gene Cause Huntington's Disease?PMID 26397895Read ↗

REVIEW-ARTICLE Intermediate alleles of Huntington's disease HTT gene in different populations worldwide: a systematic review.Semantic proximity Read ↗

Huntington's disease: how intermediate are intermediate repeat lengths?Semantic proximity Read ↗

Late-onset Huntington disease with intermediate CAG repeats: true or false?Semantic proximity Read ↗

The clinical phenotype of carriers of intermediate alleles in the huntingtin gene: A scoping review.Semantic proximity Read ↗

A series of cases with Huntington-like phenotype and intermediate repeats in HTT.Semantic proximity Read ↗

Clinical manifestations of intermediate allele carriers in Huntington disease.Semantic proximity Read ↗

Somatic CAG repeat instability in intermediate alleles of the HTT gene and its potential association with a clinical phenotype.Semantic proximity Read ↗

[The role of alleles with an intermediate number of trinucleotide repeats in Parkinson's disease and other neurodegenerative disorders].Semantic proximity Read ↗

Evidence‐based genetic counselling implications for Huntington disease intermediate allele predictive test resultsSemantic proximity Read ↗

A systematic review of the intergenerational aspects and the diverse genetic profiles of Huntington's disease.Semantic proximity Read ↗

Intermediate CAG repeats in Huntington‘s Disease: Analysis of COHORTSemantic proximity Read ↗

Predictive testing for Huntington disease: interpretation and significance of intermediate alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.