Article
Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation.
Expert opinion on biological therapy - 1 Jul 2009
Sangiolo D, Mesiano G, Carnevale-Schianca F, Piacibello W, Aglietta M, Cignetti A
Abstract excerpt
Donor lymphocyte infusion (DLI) is used to increase the graft versus tumor (GVT) effect after allogeneic hematopoietic cell transplant (HCT). The limited spectrum of activity and high risk of graft versus host disease (GVHD) remain major limitations of this approach. The finding of new cell populations for adoptive immunotherapy, with the ability to separate GVT from GVHD, would be useful. Here we review the main...
Topics
- Animals
- Clinical Trials as Topic
- Cytokine-Induced Killer Cells
- Graft vs Tumor Effect
- Hematopoietic Stem Cell Transplantation
- Humans
- Immunotherapy, Adoptive
- Lymphocytes
- Mice
- Phenotype
- Transplantation, Homologous