Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA and proteome expression profiling in early-symptomatic alpha-synuclein(A30P)-transgenic mice.

1 May 2008

Abstract excerpt

The alpha-synuclein has been implicated in the pathophysiology of Parkinson's disease (PD), because mutations in the alpha-synuclein gene cause autosomal-dominant hereditary PD and fibrillary aggregates of alpha-synuclein are the major component of Lewy bodies. Since presynaptic accumulation of alpha-synuclein aggregates may trigger synaptic dysfunction and degeneration, we have analyzed alterations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parkinson's Disease Mechanisms and Treatments
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21136867
DOI: 10.1002/prca.200780025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

MicroRNA and proteome expression profiling in early-symptomatic alpha-synuclein(A30P)-transgenic mice.PMID 21136867Read ↗

Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.Semantic proximity Read ↗

Lifetime proteomic profiling of an A30P alpha-synuclein Drosophila model of Parkinson's disease.Semantic proximity Read ↗

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease.Semantic proximity Read ↗

MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian.Semantic proximity Read ↗

Molecular signatures of altered energy metabolism and circadian rhythm perturbations in a model of extra-nigral SynucleinopathySemantic proximity Read ↗

Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.Semantic proximity Read ↗

Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice.Semantic proximity Read ↗

Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.Semantic proximity Read ↗

Early and persistent expression of phosphorylated α-synuclein in the enteric nervous system of A53T mutant human α-synuclein transgenic mice.Semantic proximity Read ↗

Influence of Different Promoters on the Expression Pattern of Mutated Human α-Synuclein in Transgenic MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.