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Influence of Different Promoters on the Expression Pattern of Mutated Human α-Synuclein in Transgenic Mice

1 Jan 2004

Abstract excerpt

Two missense mutations (A53T and A30P) in the gene encoding the presynaptic protein alpha-synuclein (asyn) are associated with rare, dominantly inherited forms of Parkinson's disease (PD) and its accumulation in Lewy bodies and Lewy neurites. As an initial step in investigating the role of asyn in the pathogenesis of PD, we have generated C57BL/6 transgenic mice overexpressing the doubly mutated human asyn under...

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PMID: 16908976
DOI: 10.1159/000085064

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