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Article

Design and characterization of an enhanced repressor of human papillomavirus E2 protein.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2011

Bose Kakoli, Meinke Gretchen, Bohm Andrew, Baleja James D

Abstract excerpt

Papillomaviruses are causative agents of cervical and anogenital cancers. The viral E2 protein mediates viral DNA replication and transactivation of viral oncogenes and thus represents a specific target for therapeutic intervention. Short forms of E2, E2R, contain only the C-terminal dimerization domain, and repress the normal function of E2 due to formation of an inactive heterodimer. Using structure-guided...

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Share to Protein Structure, Secondary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Oncogene Proteins, Viral

Share to Protein Multimerization

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Share to Spectrometry, Fluorescence

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Identifiers

PMID: 21482558
DOI: 10.1096/fj.10-176461
PMCID: PMC3114532

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