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The Structural Basis of DNA Target Discrimination by Papillomavirus E2 Proteins

1 Oct 2000

Abstract excerpt

The papillomavirus E2 proteins regulate the transcription of all papillomavirus genes and are necessary for viral DNA replication. Disruption of the E2 gene is commonly associated with malignancy in cervical carcinoma, indicating that E2 has a role in regulating tumor progression. Although the E2 proteins from all characterized papillomaviruses bind specifically to the same 12-base pair DNA sequence, the...

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PMID: 10906136
DOI: 10.1074/jbc.m004541200

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