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Evolutionary and biophysical relationships among the papillomavirus E2 proteins

1 Jan 2009

Abstract excerpt

Infection by human papillomavirus (HPV) may result in clinical conditions ranging from benign warts to invasive cancer. The HPV E2 protein represses oncoprotein transcription and is required for viral replication. HPV E2 binds to palindromic DNA sequences of highly conserved four base pair sequences flanking an identical length variable 'spacer'. E2 proteins directly contact the conserved but not the spacer DNA....

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PMID: 19273107
DOI: 10.2741/3285

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