Article
Role of envelope N-linked glycosylation in Ross River virus virulence and transmission.
The Journal of general virology - 1 May 2016
Nelson Michelle A, Herrero Lara J, Jeffery Jason A L, Hoehn Marion, Rudd Penny A, Supramaniam Aroon, Kay Brian H, Ryan Peter A, Mahalingam Suresh
Abstract excerpt
With an expanding geographical range and no specific treatments, human arthritogenic alphaviral disease poses a significant problem worldwide. Previous in vitro work with Ross River virus (RRV) demonstrated that alphaviral N-linked glycosylation contributes to type I IFN (IFN-αβ) induction in myeloid dendritic cells. This study further evaluated the role of alphaviral N-linked glycans in vivo, assessing the...
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