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Article

Association of HLA DRB1-DQB1 Haplotypes with the Risk for Neuromyelitis Optica among South Indians.

Neurology India - 1 Jan 2000

Kanikannan Meena A, Kathgave Rakesh, Yareeda Sireesha, Katkam Shiva K, Kumaraswamy Konda, Kutala Vijay K

Abstract excerpt

Background: Neuromyelitis optica (NMO) is an autoimmune demyelinating disorder, mainly characterized by severe optic neuritis, transverse myelitis and the high levels of antibodies against NMO-immunoglobulin G (IgG) or aquaporin-4 (AQP4). HLA-DR and HLA-DQ alleles within the HLA class II region on chromosome 6p21 are known to play a significant role in several autoimmune diseases including NMO. The rationale of...

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PMID: 36076647
DOI: 10.4103/0028-3886.355130

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