Article
Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids: effects of monogenic disturbances in high-density lipoprotein metabolism.
Clinical science (London, England : 1979) - 1 Apr 2012
Steiner Carine, Holleboom Adriaan G, Karuna Ratna, Motazacker Mohammad M, Kuivenhoven Jan Albert, Frikke-Schmidt Ruth, Tybjaerg-Hansen Anne, Rohrer Lucia, Rentsch Katharina M, Eckardstein Arnold von
Abstract excerpt
BA (bile acid) formation is considered an important final step in RCT (reverse cholesterol transport). HDL (high-density lipoprotein) has been reported to transport BAs. We therefore investigated the effects of monogenic disturbances in human HDL metabolism on serum concentrations and lipoprotein distributions of the major 15 BA species and their precursor C4 (7α-hydroxy-4-cholesten-3-one). In normolipidaemic...
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