Article
Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism.
Atherosclerosis - 1 Dec 2011
Karuna Ratna, Park Rebekka, Othman Alaa, Holleboom Adriaan G, Motazacker Mohammad Mahdi, Sutter Iryna, Kuivenhoven Jan Albert, Rohrer Lucia, Matile Hugues, Hornemann Thorsten, Stoffel Markus, Rentsch Katharina M, von Eckardstein Arnold
Abstract excerpt
BACKGROUND: Apolipoprotein M (apoM) has been identified as a specific sphingosine-1-phosphate (S1P) binding protein of HDL. OBJECTIVES AND METHODS: To investigate the in vivo effects of disturbed apoM or HDL metabolism we quantified S1P and apoM in plasmas of wild-type, apoM-knock-out, and apoM transgenic mice as well as 50 patients with seven different monogenic disorders of HDL metabolism and their 51...
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