Article
Activation of the SMU.1882 transcription by CovR in Streptococcus mutans.
PloS one - 22 Nov 2010
Chong Patrick, Chattoraj Partho, Biswas Indranil
Abstract excerpt
In Streptococcus mutans, the global response regulator CovR plays an important role in biofilm formation, stress-tolerance response, and caries production. We have previously shown that CovR acts as a transcriptional repressor by binding to the upstream promoter regions of its target genes. Here, we report that in vivo, CovR activates the transcription of SMU.1882, which encodes a small peptide containing a...
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