Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An essential methionine residue involved in substrate binding by phosphofructokinases.

Biochemical and biophysical research communications - 18 Sept 1998

Wang X, Deng Z, Kemp R G

Abstract excerpt

An alignment of all PPi-dependent phosphofructokinases and all allosteric ATP-dependent PFKs shows relatively few residues that are fully conserved. One residue that is conserved is a methionine residue that appears from the crystal structure of Escherichia coli PFK to be interacting with fructose 6-P. Very conservative substitutions for this methionine with leucine or isoleucine by site-directed mutagenesis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Binding Sites
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Methionine

Share to Mutation

Share to Phosphofructokinase-1

Share to Substrate Specificity

Source

Identifiers

PMID: 9753654
DOI: 10.1006/bbrc.1998.9311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An essential methionine residue involved in substrate binding by phosphofructokinases.PMID 9753654Read ↗

Identification of C-terminal motifs responsible for transmission of inhibition by ATP of mammalian phosphofructokinase, and their contribution to other allosteric effects.Semantic proximity Read ↗

Identification of substrate contact residues important for the allosteric regulation of phosphofructokinase from Eschericia coli.Semantic proximity Read ↗

Functional linkage of adenine nucleotide binding sites in mammalian muscle 6-phosphofructokinase.Semantic proximity Read ↗

Evolution of allosteric citrate binding sites on 6-phosphofructo-1-kinase.Semantic proximity Read ↗

Subunit interactions and composition of the fructose 6-phosphate catalytic site and the fructose 2,6-bisphosphate allosteric site of mammalian phosphofructokinase.Semantic proximity Read ↗

A novel form of 6-phosphofructokinase. Identification and functional relevance of a third type of subunit in Pichia pastoris.Semantic proximity Read ↗

Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants.Semantic proximity Read ↗

Mycoplasma pneumoniae HPr kinase/phosphorylase.Semantic proximity Read ↗

Structure and allosteric regulation of eukaryotic 6-phosphofructokinases.Semantic proximity Read ↗

Essential role of pyrophosphate homeostasis mediated by the pyrophosphate-dependent phosphofructokinase in Toxoplasma gondii.Semantic proximity Read ↗

Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase.Semantic proximity Read ↗

Role of Cys-295 on subunit interactions and allosteric regulation of phosphofructokinase-2 from Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.