Article
An essential methionine residue involved in substrate binding by phosphofructokinases.
Biochemical and biophysical research communications - 18 Sept 1998
Wang X, Deng Z, Kemp R G
Abstract excerpt
An alignment of all PPi-dependent phosphofructokinases and all allosteric ATP-dependent PFKs shows relatively few residues that are fully conserved. One residue that is conserved is a methionine residue that appears from the crystal structure of Escherichia coli PFK to be interacting with fructos...
Topics
- Allosteric Regulation
- Animals
- Binding Sites
- Conserved Sequence
- Entamoeba
- Escherichia coli
- Methionine
- Mutation
- Phosphofructokinase-1
- Substrate Specificity