A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting.

doi:10.1016/0092-8674(90)90070-u

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Article

A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting.

Cell - 15 Jun 1990

Rothman J H, Raymond C K, Gilbert T, O'Hara P J, Stevens T H

Abstract excerpt

Members of the Mx protein family promote interferon-inducible resistance to viral infection in mammals and act by unknown mechanisms. We identified an Mx-like protein in yeast and present genetic evidence for its cellular function. This protein, the VPS1 product, is essential for vacuolar protein...

Topics

Amino Acid Sequence
Animals
Antiviral Agents
Base Sequence
Carrier Proteins
Cloning, Molecular
Fluorescent Antibody Technique
GTP-Binding Proteins
Genotype
Immunoblotting
Molecular Sequence Data
Mutation
Myxovirus Resistance Proteins
Protein Biosynthesis
Protein Processing, Post-Translational
Proteins
Restriction Mapping
Saccharomyces cerevisiae

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Identifiers

PMID: 2112425
DOI: 10.1016/0092-8674(90)90070-u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2112425-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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