Article
A role for Lte1p (a low temperature essential protein involved in mitosis) in proprotein processing in the yeast secretory pathway.
The Journal of biological chemistry - 19 Jan 2007
Zhao Xiang, Chang Amy Y, Toh-E Akio, Arvan Peter
Abstract excerpt
We previously identified six single gene disruptions in Saccharomyces cerevisiae that allow enhanced immunoreactive insulin secretion primarily because of defective Kex2p-mediated endoproteolytic processing. Five eis mutants disrupted established VPS (vacuolar protein sorting) genes, The sixth, LTE1, is a Low Temperature (<15 degrees C) Essential gene encoding a large protein with potential guanine nucleotide...
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