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Article

PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells.

Cancer biology & therapy - 1 Feb 2011

Higgins Michaela J, Beaver Julia A, Wong Hong Yuen, Gustin John P, Lauring Josh D, Garay Joseph P, Konishi Hiroyuki, Mohseni Morassa, Wang Grace M, Cidado Justin, Jelovac Danijela, Cosgrove David P, Tamaki Akina, Abukhdeir Abde M, Park Ben Ho

Abstract excerpt

A high frequency of somatic mutations has been found in breast cancers within the gene encoding the catalytic p110α subunit of PI3K, PIK3CA. Using isogenic human breast epithelial cells, we have previously demonstrated that oncogenic PIK3CA "hotspot" mutations predict for response to the toxic effects of lithium. However, other somatic genetic alterations occur within this pathway in breast cancers, and it is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21124076
DOI: 10.4161/cbt.11.3.14227
PMCID: PMC3047087

Genes

EGFR
AKT1
EGF
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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