Article

Selinexor targets expression of metabolic genes in Merkel cell carcinoma cells

2023-10-10

Abstract excerpt

<h4>Background: </h4> Merkel cell carcinoma (MCC) is a deadly skin cancer that primarily affects the elderly and immunocompromised, with mortality rates ranging from 50% to 80%. Merkel cell polyomavirus (MCPyV) is associated with 80% of cases of MCC. The primary treatment for MCC is immune checkpoint inhibitors; however, many patients are unresponsive to or do not meet criteria for treatment. The Warburg effect ha...

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Literature Corpus work: 05f1950e-2985-598b-959f-afe9c35a800c
DOI: 10.21203/rs.3.rs-3411469/v1

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