Article
A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome.
British journal of haematology - 1 Feb 2011
Rasi Silvia, Spina Valeria, Bruscaggin Alessio, Vaisitti Tiziana, Tripodo Claudio, Forconi Francesco, De Paoli Lorenzo, Fangazio Marco, Sozzi Elisa, Cencini Emanuele, Laurenti Luca, Marasca Roberto, Visco Carlo, Xu-Monette Zijun Y, Gattei Valter, Young Ken H, Malavasi Fabio, Deaglio Silvia, Gaidano Gianluca, Rossi Davide
Abstract excerpt
Richter syndrome (RS) represents the transformation of chronic lymphocytic leukaemia (CLL) to aggressive lymphoma. Risk factors of CLL transformation to RS are only partly known. We explored the role of the host genetic background as a risk factor for RS occurrence. Forty-five single nucleotide polimorphisms (SNPs) known to be relevant for CLL prognosis were genotyped in a consecutive cohort of 331 CLL, of which...
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