The Impact of PIK3R1 Mutations and Insulin-PI3K-Glycolytic Pathway Regulation in Prostate Cancer.

doi:10.1158/1078-0432.CCR-21-4272

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Article

The Impact of PIK3R1 Mutations and Insulin-PI3K-Glycolytic Pathway Regulation in Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2022

Chakraborty Goutam, Nandakumar Subhiksha, Hirani Rahim, Nguyen Bastien, Stopsack Konrad H, Kreitzer Christoph, Rajanala Sai Harisha, Ghale Romina, Mazzu Ying Z, Pillarsetty Naga Vara Kishore, Lee Gwo-Shu Mary, Scher Howard I, Morris Michael J, Traina Tiffany, Razavi Pedram, Abida Wassim, Durack Jeremy C, Solomon Stephen B, Vander Heiden Matthew G, Mucci Lorelei A, Wibmer Andreas G, Schultz Nikolaus, Kantoff Philip W

Abstract excerpt

PURPOSE: Oncogenic alterations of the PI3K/AKT pathway occur in >40% of patients with metastatic castration-resistant prostate cancer, predominantly via PTEN loss. The significance of other PI3K pathway components in prostate cancer is largely unknown. EXPERIMENTAL DESIGN: Patients in this study underwent tumor sequencing using the MSK-IMPACT clinical assay to capture single-nucleotide variants, insertions, and...

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PMID: 35670774
DOI: 10.1158/1078-0432.CCR-21-4272
PMCID: PMC9438279

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